http://fenglaboratory.com/publications daily 0.75 2017-07-12 http://fenglaboratory.com/contact daily 0.75 2016-05-12 http://fenglaboratory.com/landing daily 0.75 2017-06-02 https://images.squarespace-cdn.com/content/v1/591c676737c5813d19a82d41/1495036194324-56NLZOG9RM3I09WIE6NE/Eamon-SQS_KEVIN_DK_0955.jpg Landing http://fenglaboratory.com/contactus daily 0.75 2026-03-09 https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/615c2455-1b7c-4dd4-95c2-d05a5eae8e53/Web+Content+2+by+3-UCSF_20190913_Feng_New_Contact+us.jpg Contact Us - Felix Feng, MD Department of Radiation Oncology University of California, San Francisco 1450 3rd Street, Room HD383 San Francisco, CA 94158 http://fenglaboratory.com/publications-1 daily 0.75 2026-03-09 https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1532645992727-XRI9J9Z7CCF59ROFRUE7/UCSF_20170828_Sunrise+MBay_006+copy.jpg Publications http://fenglaboratory.com/ongoing-projects daily 0.75 2018-08-03 https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1533279532180-9KOE2ZTAT9PGM4ML5GL3/UCSF_20170609_Social_0130.jpg Ongoing Projects https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1533327630600-5UO4ZI8QJJ4YG3G9DRUL/web1.jpg Ongoing Projects While mutations affecting protein-coding regions have been examined across many cancers, structural variants at the genome-wide level are still poorly defined. Through integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases (109X tumor/38X normal coverage), we identified structural variants altering critical regulators of tumorigenesis and progression not detectable by exome approaches. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1533324265139-7WQQZE9IJOMQ2DZH5V3Q/F1.large.jpg Ongoing Projects PCAT-1 expression leads to defective HR in prostate cells. A, left, expression level of PCAT-1 by quantitative PCR in three isogenic cell lines with overexpression (Du145, RWPE) or knockdown (LNCaP) of PCAT-1. B, expression of PCAT-1 and BRCA2 in a cohort of patients with prostate cancer. C, left, quantification of RAD51 foci in isogenic Du145 and LNCaP cell lines following 2 Gy of radiation or treatment with 25 μmol/L olaparib. D, I-SceI–mediated GFP HR assay in PC3-PCAT-1 cells compared with matched control cells. Error bars, SEM. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1533326259171-7869IIWGZMCTMZEKX2U8/10.1200-JCO.2006.06.4246Figure1+%281%29.jpg Ongoing Projects S9346 (INT- 0162) study schema. D2, metastatic; PSA, prostate-specific antigen; ADT, androgen-deprivation therapy. http://fenglaboratory.com/copy-of-home-travis daily 1.0 2022-10-27 https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1532642969120-SJ0A8R5NMVNGPJ0FTYM9/golden-gate-bridge-side-view-at-night-wallpaper-1.jpg Home OUR MISSION TO IMPROVE OUTCOMES FOR PATIENTS WITH AGGRESSIVE CANCER https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1532636618050-8UPFY07FXE99U6L2ES5J/water-horizon-sky-skyline-night-house-1218695-pxhere.com.jpg Home WE DISCOVER NOVEL PROGNOSTIC AND PREDICTIVE BIOMARKERS https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1532637909050-5I1HXMNT814G9GZ6CEQP/DNA.jpg Home WE INVESTIGATE MOLECULAR MECHANISMS THAT DRIVE DISEASE PROGRESSION https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1532644153588-TM9IJXMRSV2PYTGT2PSB/IMG_0186.JPG Home WE WORK TOGETHER TO ACHIEVE OUR RESEARCH GOALS https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1533657934981-BI3QTRG75KVHCUJMOCQI/fun.jpg Home The Feng Lab is comprised of exceptional biologists and computational scientists, working together to advance our understanding of cancer biology with the aim of improving patient outcomes. We focus on identifying molecular drivers of cancer pathogenesis and understanding the mechanisms that contribute to disease progression and metastasis, the discovery of prognostic and predictive biomarkers to advance precision cancer medicine, and novel therapeutic strategies to fight cancer and benefit patient care. http://fenglaboratory.com/activitiesphotos daily 0.75 2024-08-21 https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1547502813797-TAIS0BC1BNNM5JYMDQYF/08-19-2018_SFA_TM_WWE_I00040017.jpg Activities and Photos https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1724271055737-T96U7W0R60U56BIJL4G0/Lab+-+climbing.jpeg Activities and Photos https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1724271054155-TIM1R30UYZRGFUNPJ90W/Lab+-+farewell+party.jpeg Activities and Photos https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1724271059287-4RO6FSOEDXRS061EXLRZ/Lab+-+game+1.jpeg Activities and Photos 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https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1532553433503-ME7X2GSXJ2D9OOEFIMXV/Felix_Feng.jpg Team - Felix Feng, MD On December 10th, 2024, our cherished friend and colleague Felix Feng, MD, passed after a long fight with cancer. We offer our deepest condolences to Felix’s family, friends, and all who had the privilege of knowing him. Professor of Radiation Oncology, Urology, and Medicine George and Judy Marcus Distinguished Professor Vice Chair for Translational Research, Dept. of Radiation Oncology Director, Benioff Initiative for Prostate Cancer Research Associate Director of Clinical Translational Research, Helen Diller Family Comprehensive Cancer Center https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1552327948433-DDZRA22V4E0729DDLQ4T/Lisa_20171214-IMG_7832.jpg Team Lisa received her undergraduate degree from the University of Wisconsin- Eau Claire and completed her MS and PhD in Pharmacology from the University of Minnesota- Twin Cities. She joined the Feng Lab in 2018 as a postdoctoral scholar and is now a professional researcher in the lab. Her work focuses on understanding mechanisms of MHC regulation in prostate cancer as well as identifying synthetic lethal targets in ATM-deficient prostate cancer. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1df9ab55-57d6-4718-b9ee-d25804b1ca9d/Xiaolin+Zhu.jpg Team - Make it stand out Xiaolin is a medical oncology fellow at UCSF. He is interested in understanding human cancer biology through profiling patient samples and translating the insights into novel therapeutic strategies. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/e19933ff-d6d7-441f-89e3-2c70de359185/Jun+Zhu.PNG Team - Make it stand out Jun is an associate specialist in Feng lab at UCSF. Jun earned his MD degree from Tianjin Medical University. Jun worked as a pathologist in the neuro-pathology department at Tianjin Medical University General Hospital. In pursuit of this passion, Jun joined UCSF as a postdoctoral fellow under the guidance of Dr. Farid Chehab. In 2020, Jun joined Dr. Felix Feng's lab. Jun is motivated to use his medical knowledge and research expertise to advance life-saving missions. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/a5550c13-4df8-4c67-a550-e9a075b0c3d3/PXL_20230722_041001432.jpg Team Mikhail completed his Ph.D at the Peter MacCallum Cancer Centre and the University of Melbourne. His research interests lie in comprehending the role of gene regulation alterations facilitating tumour progression and therapy resistance. When he’s not in the lab, you’ll often find him hiking, biking, climbing, or experimenting with new recipes in the kitchen. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1532493482583-I5B7QQ9K4Q3X2K6VSG0D/final.png Team Adam manages the Tissue Core for the BIPCR and oversees the lab operations for the metastatic prostate cancer biopsy program and associated NGS laboratory. He has a BS from Haverford College in chemistry and biophysics and over 15yrs experience in lab management and NGS lab operations with a specific focus on optimizing CT-guided bone biopsies for multi-omics investigation of metastatic prostate cancer. Adam joined UCSF's HDFCCC in 2010, where he leveraged experience with mCRPC bone metastasis and gene expression assays at Duke University to build the infrastructure and NGS pipelines behind the Stand Up to Cancer West Coast Dream Team program at UCSF. The biobank and constantly growing NGS infrastructure continues to support new multi-year, multi-institutional clinical programs in metastatic prostate cancer through the Feng laboratory, the UCSF HDFCCC, and the BIPCR. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/39fa33e4-45cd-47e3-ae2a-31a0ded20890/Noah+Younger_headshot_revised.jpg Team - Make it stand out Noah is a physician-scientist with a research background in drug development. He sees patients with advanced genitourinary malignancies in clinic, while working in the Feng lab to identify new therapeutic targets in prostate cancer. Outside of lab and clinic he enjoys spending time with his partner and 6 month old son. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/c6d4114c-a183-4b2e-bbd4-9017f5bfebee/Nolley_Rosalie_headshot.jpg Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/0a637192-75e7-4550-9dc9-abde245b3993/Emma+Dolan+Headshot.jpg Team Emma was born and raised in West Virginia. She earned a B.S. in Biochemistry from West Virginia University, followed by a post-baccalaureate research fellowship at the National Institutes of Health. She earned a Ph.D. in Pharmacology from Duke University prior to joining the Feng lab in 2023. Her research interests include exploiting cancer cell-intrinsic molecular mechanisms for clinical therapeutic improvements. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/435262e0-2757-48e9-888b-e226b3b1addc/Rensheng+Wan.jpg Team Rensheng is a Postdoctoral Fellow at UCSF. She finished her doctoral degree in Genetics. Now she works in understanding human cancer biology by profiling patient samples and identifying biomarkers to predict patients' outcome. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/07733ddc-d077-45f8-b5ae-c0443875760c/Alexis+Smith.jpg Team - Make it stand out Alexis is a Junior Specialist exploring new combination therapies for patients with prostate cancer. She received her undergraduate degree from Kennesaw State University and her master's degree from Touro University California. Alexis enjoys live music and exploring the great outdoors in her free time. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/c9320787-a5ce-4d15-9e8f-a8ca1751a338/thaidy_rodriguez_300_300.jpg Team - Make it stand out Thaidy received her Ph.D. in Molecular Biology and Biomedicine from the Universidad de Cantabria in Spain. Her research interests are centered around how tumors develop resistance to targeted therapy in prostate cancer. Outside of the lab, she enjoys outdoor activities while exploring California. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/5e608001-7788-4bdb-87e9-14b95f872006/Stanley.jpg Team - Make it stand out Specialist with focus on deploying NGS techniques including long-range sequencing and spatial transcriptomics. Raising a budding scientist-foodie -- AMA about food, babies, or science. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/b22186d5-5ea5-46ae-87b3-a668ff2a3ed0/Jason+Swinderman.png Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/c035e17d-d570-40bd-903d-9175ac50b18b/Gabriel+Eades.jpg Team - Make it stand out Dr. Gabriel Eades is a postdoctoral researcher in the Feng laboratory. He completed his undergraduate degree at Virginia Commonwealth University and completed his doctoral research training at the University of Maryland, Baltimore. His research aims to develop and apply novel tools and technologies to map the genetic interactions driving drug resistance in mCRPC and to apply functional genomics tools to identify druggable dependencies. In addition, he is working to address a major challenge facing researchers, that of the limited number of available prostate cancer models. He is aiming to establish the next generation of prostate cancer research models working towards providing prognostic patient avatars. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/872ae5a6-a142-43a1-9a25-0570357e6f96/Allegra+Headshot.jpg Team - Make it stand out Allegra brings her expertise as a recent addition to the Feng Lab, where she works as a postdoctoral researcher. She earned her PhD from the Garvan Institute of Medical Research/UNSW in Sydney, Australia, specializing in hormone receptor biology and mechanisms of therapy resistance in ER+ breast cancer. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/ca1e8af2-d978-4f5d-8c0a-037c6f3fbd78/Aish.PNG Team - Make it stand out Aish has been a member of the Feng Lab since 2023 and her focus in the lab is on translational computational research (such as biomarker development, etc.). She aspires to be a future physician scientist. Outside the lab, she enjoys playing board games, running marathons, and trying out new food in SF. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/544e8f1b-78e3-4b62-a14a-f8339989e4e7/Josephine+Hinneh.jpg Team - Make it stand out Josephine is a postdoctoral scholar in the Feng lab with a strong interest in using genomic approaches to identify durable drug targets for advanced prostate cancer. She holds a BPharm from the University of Ghana, an MSc from Mie University in Japan and a jointly awarded PhD from The University of Adelaide in Australia and Nagoya University in Japan. Josephine brings on board her expertise in androgen receptor biology and drug resistance. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1602628726176-NGG6ABXS2I6G8NTM0IDN/Jun+Zhu_Cropped.jpg Team Jun is an associate specialist in Feng lab at UCSF. Jun earned his MD degree from Tianjin Medical University. Jun worked as a pathologist in the neuro-pathology department at Tianjin Medical University General Hospital. In pursuit of this passion, Jun joined UCSF as a postdoctoral fellow under the guidance of Dr. Farid Chehab. In 2020, Jun joined Dr. Felix Feng's lab. Jun is motivated to use his medical knowledge and research expertise to advance life-saving missions. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/3e38bf74-25f2-4f31-89e9-97966a343440/Blank+Profile+Pic.PNG Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/93f6cc4b-d9ea-456d-9dc7-7467c0f95ec7/Derek+.jpeg Team - Make it stand out Derek is a UCB undergraduate interested in the field on oncology. I'm working on figuring out genes in cancer that can be potentially therapeutic targets! https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/c72d7876-b9de-4ef9-a90d-3814310e6a3c/Fiona+MacLeitch.jpeg Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/3e38bf74-25f2-4f31-89e9-97966a343440/Blank+Profile+Pic.PNG Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1532492236485-YJOBA77MJLSIAD132I9L/unnamed+%281%29.png Team https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1532492886676-SYX9B147D0BE5D7KSMG2/Chou_Jonathan+headshot.jpg Team https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/1299412c-50bf-4510-acd3-61ccd49e9ce5/Cornelia+Ding.jpg Team - Make it stand out Mom, uropathologist, molecular biologist, and choir singer. https://images.squarespace-cdn.com/content/v1/5733887320c647d7f0567a23/5837c959-5eff-477e-ba73-00ef13252f90/blank.jpg Team - Make it stand out Whatever it is, the way you tell your story online can make all the difference. http://fenglaboratory.com/partners-bedford daily 0.75 2025-05-12 https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390505394162-W51WFS0M8F9TXWY7LPDY/chambers-10.jpg Partners https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390409437321-Q9EZYDA52XWMFWJIQRU6/logo-2.jpg Partners https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390409437266-8DADKO4VSI8O9JEYQ58I/logo-4.jpg Partners https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390409437284-U9500QOC95REDBT90G9L/logo-1.jpg Partners https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390409437242-8SZY5F04GD012C425QZ6/logo-3.jpg Partners http://fenglaboratory.com/what-we-do-bedford daily 0.75 2025-05-12 https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390513380961-PTHFXE5U2S1FJSLPXUSD/tumblr_mh1iruZWLf1rkz363o1_1280.jpg What We Do http://fenglaboratory.com/contact-bedford daily 0.75 2025-05-12 https://images.squarespace-cdn.com/content/v1/52a74d9ae4b0253945d2aee9/1390510556456-TV8RZ8LOBB3L6TBXFWZD/tumblr_mkrr2pZQ851rkz363o2_1280.jpg Contact